Potassium Carbonate → 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

HRID 1798948노트

반응식

HRID 1798948 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17]Cl)=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CCO>[Cl:10][C:11]1[N:12]=[CH:13][C:14]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]2)=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 780131-IsopropylpiperazineHCID 1554792-Chloro-5-(chloromethyl)pyridine

생성물 1

HCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
65 °C

실험 절차

Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.

후처리

  1. customa strongly exothermic reaction
  2. filtrationThe reaction mixture was filtered
  3. customevaporated
  4. customThe crude product was used without any further purification

출처 및 근거

ORD 기록
ord-0f22ffb33d324a43b8d7b507ff606544
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344001B2

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