2-Methylpyridine-4-boronic acid → 5-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride

HRID 1798949노트

반응식

HRID 1798949 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:18][C:19]1[CH:24]=[C:23](B(O)O)[CH:22]=[CH:21][N:20]=1>>[ClH:1].[ClH:1].[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([C:23]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:18])[CH:24]=3)=[N:7][CH:6]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]

참가 물질

3

반응물 2

HCID 41926642-Methylpyridine-4-boronic acidHCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

생성물 1

HCID 1317301375-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride

실험 절차

1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.2 g, 0.788 mmol) and 2-methylpyridin-4-boronic acid (0.119 g, 0.867 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as yellow crystals of the trihydrochloride. Yield: 295 mg (73%).

후처리

  1. customreacted in the same manner as in example 18

출처 및 근거

ORD 기록
ord-df55b194c1214e7ca136b92876f79dd9
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344001B2

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