1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine → 4-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride
반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:18][N:19]([CH3:32])[S:20]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)(=[O:22])=[O:21]>>[ClH:1].[ClH:1].[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([C:26]3[CH:25]=[CH:24][C:23]([S:20]([N:19]([CH3:32])[CH3:18])(=[O:21])=[O:22])=[CH:28][CH:27]=3)=[N:7][CH:6]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]참가 물질
3
실험 절차
1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.5 g, 1.97 mmol) and 4-(N,N-dimethylaminosulfonyl)phenylboronic acid (0.496 g, 2.2 mmol)) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the trihydrochloride. Yield: 660 g (71%)
후처리
- customreacted in the same manner as in example 18
출처 및 근거
- ORD 기록
- ord-3cb89b0f36104ff1830c969c608a4ac6
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08344001B2
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