Potassium Carbonate → HCID 58433490, 화합물

HRID 1798956노트

반응식

HRID 1798956 반응식
[C:1]1([C:7]2(NC)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:16]1[C:21]([Cl:22])=[CH:20][C:19]([C:23]([F:26])([F:25])[F:24])=[CH:18][N:17]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:33][N:34]1C(=O)CCC1>>[Cl:22][C:21]1[C:16]([NH:34][CH2:33][C:7]2([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:20]=1

참가 물질

5

반응물 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 262910N-Methyl-1-phenylcyclohexanamine

생성물 1

HCID 58433490HCID 58433490, 화합물

실험 절차

was prepared from 475 mg of 1-phenyl-cyclohexyl-methylamine by reaction with 596 mg of 2,3-dichloro-5-trifluoromethyl-pyridine in the presence of 354 mg potassium carbonate in 2.5 ml of NMP at 80° C. for 1 hour. After dilution with 20 ml of water, the product was extracted with 30 ml of ethyl acetate and purified by chromatography on silica gel with the eluents dichloromethane:methanol=98:2 to obtain 469 mg g of a light yellow oil.

후처리

  1. extractionAfter dilution with 20 ml of water, the product was extracted with 30 ml of ethyl acetate
  2. custompurified by chromatography on silica gel with the eluents dichloromethane
  3. custommethanol=98:2 to obtain 469 mg g of a light yellow oil

출처 및 근거

ORD 기록
ord-9bf982e80f6d48d8aa002d8d0c53d794
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344004B2

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