Chlorosulfonic acid → HCID 58433497, 화합물

HRID 1798957노트

반응식

HRID 1798957 반응식
[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:26][S:27](O)(=[O:29])=[O:28]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][C:23]([S:27]([Cl:26])(=[O:29])=[O:28])=[CH:22][CH:21]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 58433490HCID 58433490, 화합물

생성물 1

HCID 58433497HCID 58433497, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

185 mg of (3-Chloro-5-trifluoromethyl-pyridin-2-yl)-(1-phenyl-cyclohexylmethyl)-amine were dissolved in 15 ml of methylenchloride and 0.14 ml of chlorosulfonic acid were added. The reaction mixture was stirred at room temperature for 4 days and than poured on ice water (20 ml). The organic layer was separated, washed twice with 50 ml of brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 194 mg g of the crude product.

후처리

  1. additionthan poured on ice water (20 ml)
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml of brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-d9707b838f96458a80063c53f79f016e
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344004B2

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