1,4-Dioxane hydrochloride → N,N-dimethylazetidine-3-carboxamide hydrochloride
반응식
[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17].O1CCOCC1>>[ClH:17].[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][NH:7][CH2:6]1)=[O:4]참가 물질
3
실험 절차
A mixture of t-butyl 3-dimethylcarbamoyl-azetidine-1-carboxylate (0.365 g) and 4N hydrogen chloride/dioxane solution (5 ml) was stirred at room temperature for 5 hr 15 min. The reaction mixture was concentrated under reduced pressure, dioxane was added to the obtained residue and the mixture was concentrated again under reduced pressure. The obtained residue was dried under reduced pressure at 60° C. to give the title compound (0.290 g). The obtained residue was directly used for the next reaction without further purification.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure, dioxane
- additionwas added to the obtained residue
- concentrationthe mixture was concentrated again under reduced pressure
- customThe obtained residue was dried under reduced pressure at 60° C.
출처 및 근거
- ORD 기록
- ord-3952b8cd197842188963e54652bc2976
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08343994B2
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