Glycine ethyl ester → HCID 59225865, 화합물

HRID 1799148

반응식

[Br:1][C:2]1[N:6]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=2)[C:5]([S:19][CH2:20][C:21]([NH:23][CH2:24][C:25]([OH:27])=O)=[O:22])=[N:4][CH:3]=1.C([O:30][C:31](=[O:34])[CH2:32][NH2:33])C.BrC1N(C2C3C(=CC=CC=3)C(C#N)=CC=2)C(SCC(O)=O)=NC=1.NCC(NCC(OCC)=O)=O>>[Br:1][C:2]1[N:6]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=2)[C:5]([S:19][CH2:20][C:21]([NH:23][CH2:24][C:25]([NH:33][CH2:32][C:31]([OH:34])=[O:30])=[O:27])=[O:22])=[N:4][CH:3]=1

참가 물질

반응물 4

HCID 12176Glycine ethyl ester

HCID 124706Ethyl glycylglycinate

HCID 46178862HCID 46178862, 화합물

HCID 59225886HCID 59225886, 화합물

생성물 1

HCID 59225865HCID 59225865, 화합물

실험 절차

2-(2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetamido)acetic acid is prepared via either of the two routes shown below. In the first, 2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetic acid (see eg 3) is coupled with glycine ethyl ester and then hydrolyzed to the acid. In the second, 2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetic acid (see eg 1) is coupled with NH2-Gly-Gly-OEt, which is then hydrolyzed to the acid.

출처 및 근거

ORD 기록: ord-50f30fdc752747649bce631081b9ad76
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08344012B2

연결된 노트

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