Methylparaben → N-[4-(Cyclobutylmethoxy)benzoyl]glycine

반응식

[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[CH:19]=[CH:18][C:10]([C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.OC1C=CC(C(OC)=O)=CC=1.C1(CO)CCC1>>[CH:4]1([CH2:5][O:6][C:7]2[CH:8]=[CH:9][C:10]([C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])=[CH:18][CH:19]=2)[CH2:2][CH2:3][CH2:1]1

참가 물질

반응물 3

HCID 7456Methylparaben

HCID 78130Cyclobutylcarbinol

HCID 66812105N-[4-(2-Cyclopropylethoxy)benzoyl]glycine

생성물 1

HCID 66812262N-[4-(Cyclobutylmethoxy)benzoyl]glycine수율 97%

실험 절차

Reactions similar to those described in Example 1 (1a) and (1b) were conducted using methyl 4-hydroxybenzoate (3.81 g, 25.0 mmol) and cyclobutylmethanol (2.36 mL, 25.0 mmol) to give 6.41 g of the title compound (white powder, yield: 97%).

출처 및 근거

ORD 기록: ord-ebc9c3e73fc547c98440695ea6121c24
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08344029B2

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