4-(4-(Trifluoromethyl)phenoxy)benzoic acid → 2-{[(2S)-3-[4-(Trifluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate

HRID 1799275

반응식

HRID 1799275 반응식
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH2:22])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[F:24][C:25]([F:43])([F:42])[C:26]1[CH:41]=[CH:40][C:29]([O:30][C:31]2[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=2)=[CH:28][CH:27]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH:22][C:35](=[O:36])[C:34]1[CH:38]=[CH:39][C:31]([O:30][C:29]2[CH:40]=[CH:41][C:26]([C:25]([F:24])([F:42])[F:43])=[CH:27][CH:28]=2)=[CH:32][CH:33]=1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 36734814-(4-(Trifluoromethyl)phenoxy)benzoic acidHCID 690175432-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

생성물 1

HCID 866365302-{[(2S)-3-[4-(Trifluoromethoxy)phenyl]-2-({4-[4-(trifluoromethyl)phenoxy]benzoyl}amino)propanoyl]amino}ethyl acetate

실험 절차

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-[4-(trifluoromethyl)phenoxy]benzoic acid used in Example 41 (41a) to give the title compound.

후처리

  1. customA reaction similar to

출처 및 근거

ORD 기록
ord-acb4ef0b838949ef99a5959908f8b788
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344029B2

연결된 노트

불러오는 중…