반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:27])[C:10](=[O:26])[N:11]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH3:25])[C:12]=2[C:16]([O:18]C)=[O:17])[C:7]1=[O:28].[OH-].[K+].O1CCCC1CO.O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:27])[C:10](=[O:26])[N:11]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH3:25])[C:12]=2[C:16]([OH:18])=[O:17])[C:7]1=[O:28]참가 물질
4
반응물 3
생성물 1
반응 조건
- 온도
- 50 °C
실험 절차
Methyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-[4-(methylamino)butyl]-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate (0.18 g, 0.38 mmol) and potassium hydroxide (0.17 g, 2.3 mmol) in a mixture of 1:1:1 v/v/v tetrahydrofuran-methanol-water (4.5 mL) was heated at 50° C. overnight. The reaction mixture was concentrated under vacuum. The residue was partitioned between dichloromethane and dilute hydrochloric acid. The aqueous extract was concentrated under vacuum to provide the title compound as hydrochloride salt. This was used in the following step without further purification. ES MS M+1=452
후처리
- concentrationThe reaction mixture was concentrated under vacuum
- customThe residue was partitioned between dichloromethane and dilute hydrochloric acid
- extractionThe aqueous extract
- concentrationwas concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-edb76f37641c463b8fafa3e58110303d
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741315B2
연결된 노트
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