Formic Acid → 5-Bromo-2-nitrothiophene-3-carbaldehyde

HRID 1799537

반응식

HRID 1799537 반응식
[Br:1][C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([CH:10](Cl)Cl)[CH:3]=1.C(O)=[O:14]>[Cl-].[Zn+2].[Cl-].O>[Br:1][C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([CH:10]=[O:14])[CH:3]=1

참가 물질

5

반응물 2

HCID 284Formic AcidHCID 595256075-Bromo-3-(dichloromethyl)-2-nitrothiophene

생성물 1

HCID 534029475-Bromo-2-nitrothiophene-3-carbaldehyde

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 962Water용매

실험 절차

5-Bromo-3-(dichloromethyl)-2-nitrothiophene (60.5 g, 208 mmol) and zinc chloride (113 g, 832 mmol) were stirred in refluxing formic acid (800 mL) overnight. After cooling to ambient temperature, water was added and the mixture was extracted with EtOAc (4×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as an orange solid.

후처리

  1. extractionthe mixture was extracted with EtOAc (4×)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5477ffb4efa64e4b874a8995a20ddef3
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344144B2

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