Carbonic acid, 1-ethylpropyl iodomethyl ester → HCID 69470299, 화합물

HRID 1799719노트

반응식

HRID 1799719 반응식
[OH:1][C@@H:2]([C@H:4]1[C:24](=[O:25])[N:6]2[C:7]([C:21]([O-:23])=[O:22])=[C:8]([S:11]/[CH:12]=[CH:13]\[C:14]3[S:18][CH:17]=[N:16][C:15]=3[CH2:19][OH:20])[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[Na+].[CH2:27]([CH:29]([O:32][C:33]([O:35][CH2:36]I)=[O:34])[CH2:30][CH3:31])[CH3:28]>>[OH:1][C@@H:2]([C@H:4]1[C:24](=[O:25])[N:6]2[C:7]([C:21]([O:23][CH2:36][O:35][C:33]([O:32][CH:29]([CH2:30][CH3:31])[CH2:27][CH3:28])=[O:34])=[O:22])=[C:8]([S:11]/[CH:12]=[CH:13]\[C:14]3[S:18][CH:17]=[N:16][C:15]=3[CH2:19][OH:20])[C@H:9]([CH3:10])[C@H:5]12)[CH3:3]

참가 물질

3

반응물 2

HCID 12098199Carbonic acid, 1-ethylpropyl iodomethyl esterHCID 23676797Sodium (1r,5s,6s)-6-((1r)-1-hydroxyethyl)-2-[[(z)-2-(4-hydroxymethyl-thiazol-5-yl)ethen-1-yl]thio]-1-methyl-1-carbapen-2-em-3-carboxylate

생성물 1

HCID 69470299HCID 69470299, 화합물수율 79.4%

실험 절차

In the same manner as in Example 81, 154 mg of the title compound was prepared from 149 mg of sodium (1R,5S,6S)-6-((1R)-1-hydroxyethyl)-2-[[(Z)-2-(4-hydroxymethylthiazol-5-yl)ethen-1-yl]thio]-1-methyl-1-carbapen-2-em-3-carboxylate and 120 mg of (1-ethylpropan-1-yl)oxycarbonyloxymethyl iodide.

출처 및 근거

ORD 기록
ord-cc31ab1628b242ccbf569d1d623dc9ce
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344154B2

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