Hydrogen chloride-ethyl acetate → 6-Azaspiro[2.5]octane--hydrogen chloride (1/1)

HRID 1800604

반응식

HRID 1800604 반응식
[CH2:1]1[C:3]2([CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]2)[CH2:2]1.[ClH:16].C(OCC)(=O)C>O1CCCC1>[ClH:16].[CH2:2]1[C:3]2([CH2:8][CH2:7][NH:6][CH2:5][CH2:4]2)[CH2:1]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 51358341Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate

생성물 1

HCID 545931876-Azaspiro[2.5]octane--hydrogen chloride (1/1)수율 85.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (261 mg, 1.23 mmol) was dissolved in tetrahydrofuran (5 mL), 4N hydrochloric acid/ethyl acetate solution (2 mL, 8.00 mmol) was added, and the mixture was stirred at 50° C. for 24 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (155 mg, 85%) as white crystals.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e4b3a222fdea47e4ac21dbf20233476a
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344135B2

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