Diethylamine → 2-Chloro-N,N-diethylnicotinamide

HRID 1801493

반응식

HRID 1801493 반응식
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:11]([NH:13][CH2:14][CH3:15])[CH3:12]>ClCCl>[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:13]([CH2:14][CH3:15])[CH2:11][CH3:12])=[O:5]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 27745412-Chloronicotinoyl chloride

생성물 1

HCID 44659442-Chloro-N,N-diethylnicotinamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-chloronicotinoyl chloride (20.0 g, 114.3 mmol) in dichloromethane (100 mL) at 0° C. was added diethylamine (23.7 mL, 228.6 mmol). The reaction mixture was stirred overnight at room temperature, washed with water (3×100 mL), dried over sodium sulfate and concentrated under reduced pressure to provide the desired product as a brown oil. LC MS: 213 [M+H]. The crude product was used in Step 2 without any further purification.

후처리

  1. washwashed with water (3×100 mL)
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7f887e8b1a2647beba2c6d228f3f17eb
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349827B2

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