Tetrahydrofurfurylamine → 6-(6-((Tetrahydrofuran-2-yl)methylamino)pyridin-3-yl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

HRID 1801692노트

반응식

HRID 1801692 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[NH:16][C:15]3[C:14](=[O:17])[N:13]([CH2:18][CH2:19][CH3:20])[C:12](=[O:21])[N:11]([CH2:22][CH2:23][CH3:24])[C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.[CH2:25]([NH2:31])[CH:26]1[O:30][CH2:29][CH2:28][CH2:27]1>CCO>[O:30]1[CH2:29][CH2:28][CH2:27][CH:26]1[CH2:25][NH:31][C:2]1[N:7]=[CH:6][C:5]([C:8]2[NH:16][C:15]3[C:14](=[O:17])[N:13]([CH2:18][CH2:19][CH3:20])[C:12](=[O:21])[N:11]([CH2:22][CH2:23][CH3:24])[C:10]=3[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 253298TetrahydrofurfurylamineHCID 598566326-(6-chloropyridin-3-yl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

생성물 1

HCID 598566296-(6-((Tetrahydrofuran-2-yl)methylamino)pyridin-3-yl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione수율 82.1%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
164 °C

실험 절차

8a (154 mg) was suspended in tetrahydrofurfurylamine (2.0 g) in EtOH (5 ml) in a pressure tube and stirred at 164° C. for 5 days. After cooling to room temperature, the solid was filtered and washed with methanol to give the product (9b) (150 mg).

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered
  3. washwashed with methanol

출처 및 근거

ORD 기록
ord-833242f3c19641f7b497ed34068ca53e
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349848B2

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