4-Amino-1-butanol → 4-Tert-butoxycarbonylmethylamino-1-butanol

HRID 18017

반응식

HRID 18017 반응식
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].Br[CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>C(OCC)C>[C:12]([O:11][C:9](=[O:10])[CH2:8][NH:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])([CH3:15])([CH3:14])[CH3:13]

참가 물질

4

반응물 2

HCID 258684-Amino-1-butanolHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 108458284-Tert-butoxycarbonylmethylamino-1-butanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a cold (0° C.) solution of 4-hydroxybutylamine (9.1 g, 101.8 mmol) in diethyl ether (100 mL), a solution of tert-butyl bromoacetate (7.4 g, 49.3 mmol) in diethyl ether (25 mL) was added dropwise over a period of 2 hours. The reaction mixture was allowed to warm up slowly to room temperature and stirred at the temperature overnight. The product mixture was washed successively with aqueous NaHCO3, water, and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. This intermediate was used in the following reaction without further purification.

후처리

  1. washThe product mixture was washed successively with aqueous NaHCO3, water, and brine
  2. extractionThe organic extract
  3. dry with materialwas dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum
  6. customThis intermediate was used in the following reaction without further purification

출처 및 근거

ORD 기록
ord-301a1819b29342888da55e194bb046f4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741315B2

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