Thionyl Chloride → 3-(Chloromethyl)-9h-pyrido[3,4-b]indole

HRID 1801705노트

반응식

HRID 1801705 반응식
O[CH2:2][C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[CH:15]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3.S(Cl)([Cl:18])=O>>[Cl:18][CH2:2][C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[CH:15]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 53533383-Hydroxymethyl-beta-carboline

생성물 1

HCID 201484093-(Chloromethyl)-9h-pyrido[3,4-b]indole

실험 절차

The 3-(hydroxymethyl)-β-carboline was added to an excess (3 grams) of thionyl chloride and the mixture was refluxed for 1 hour. The excess thionyl chloride was then evaporated and the obtained residue was crystallized from hexane. 2.5 grams of 3-(chloromethyl)-β-carboline was obtained.

후처리

  1. temperaturethe mixture was refluxed for 1 hour
  2. customThe excess thionyl chloride was then evaporated
  3. customthe obtained residue was crystallized from hexane

출처 및 근거

ORD 기록
ord-5c3747e1672c4507b59c422a03b60acf
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349850B2

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