1-(2-fluoro-4-nitrophenyl)-1H-imidazole → 3-fluoro-4-(1H-imidazol-1-yl)aniline

HRID 1802012노트

반응식

HRID 1802012 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

참가 물질

4

반응물 1

HCID 53061531-(2-fluoro-4-nitrophenyl)-1H-imidazole

생성물 1

HCID 103749763-fluoro-4-(1H-imidazol-1-yl)aniline수율 88.5%

시약·촉매·용매 2

HCID 887Methanol촉매HCID 23938Palladium촉매

실험 절차

A mixture of 1-(2-fluoro-4-nitrophenyl)-1H-imidazole (1.81 g, 8.74 mmol) and Pd—C (10%, 0.200 g) in MeOH (20 mL) (containing 10 drops of 6N HCl) was hydrogenated under balloon H2 overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo. The residue was dried on vacuum to give 3-fluoro-4-(1H-imidazol-1-yl)benzenamine as a solid (1.37 g). MS178.3 (M+H)

후처리

  1. customwas hydrogenated under balloon H2 overnight
  2. filtrationThe mixture was filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was dried on vacuum

출처 및 근거

ORD 기록
ord-ba7a3d2679274d2493f6c090e38e9731
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349860B2

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