Sodium Methoxide → HCID 59435979, 화합물

HRID 1802478노트

반응식

HRID 1802478 반응식
[Br:1][C:2]1[CH:26]=[CH:25][C:5]2[N:6]=[C:7]([NH:15][C:16]3[C:21]([Cl:22])=[CH:20][C:19]([I:23])=[CH:18][C:17]=3[Cl:24])[C:8]3[C:13]([C:4]=2[CH:3]=1)=[C:12](Cl)[N:11]=[CH:10][CH:9]=3.[CH3:27][O-:28].[Na+]>CO.O>[Br:1][C:2]1[CH:26]=[CH:25][C:5]2[N:6]=[C:7]([NH:15][C:16]3[C:21]([Cl:22])=[CH:20][C:19]([I:23])=[CH:18][C:17]=3[Cl:24])[C:8]3[C:13]([C:4]=2[CH:3]=1)=[C:12]([O:28][CH3:27])[N:11]=[CH:10][CH:9]=3

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 594359979-Bromo-1-chloro-N-(2,6-dichloro-4-iodophenyl)benzo[c]-2,6-naphthyridin-5-amine

생성물 1

HCID 59435979HCID 59435979, 화합물

시약·촉매·용매 2

HCID 962Water촉매HCID 887Methanol용매

실험 절차

To a solution of 9-bromo-1-chloro-N-(2,6-dichloro-4-iodophenyl)benzo[c]-2,6-naphthyridin-5-amine (1.56 g, 2.69 mmol) in methanol (30 mL) was added sodium methoxide (10 mL, 25% in methanol) and heated the reaction to 100° C. for 45min. The reaction was cooled to room temperature and a few drops of water were added to quench the reaction. The organic layer was evaporated under vacuum and the residue was diluted with ethyl acetate and extracted with water. The organic layer was separated, dried with sodium sulfate, filtered and evaporated. The residue was taken to the next step without purification.

후처리

  1. temperatureheated
  2. customthe reaction to 100° C. for 45min
  3. customto quench
  4. customthe reaction
  5. customThe organic layer was evaporated under vacuum
  6. additionthe residue was diluted with ethyl acetate
  7. extractionextracted with water
  8. customThe organic layer was separated
  9. dry with materialdried with sodium sulfate
  10. filtrationfiltered
  11. customevaporated
  12. customThe residue was taken to the next step without purification

출처 및 근거

ORD 기록
ord-d399cf71e31048a5be52dc6f2970457b
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349865B2

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