2-methylimidazo[1,2-a]pyridine-3-carbaldehyde → HCID 67159028, 화합물

HRID 1802769노트

반응식

HRID 1802769 반응식
[Cl-].C1([P+](C2C=CC=CC=2)(C2C=CC=CC=2)[CH2:9][O:10][CH2:11][CH2:12][Si:13]([CH3:16])([CH3:15])[CH3:14])C=CC=CC=1.[CH3:29][C:30]1[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]2[C:38]=1[CH:39]=O>>[CH3:29][C:30]1[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]2[C:38]=1[CH:39]=[CH:9][O:10][CH2:11][CH2:12][Si:13]([CH3:14])([CH3:15])[CH3:16]

참가 물질

3

반응물 2

HCID 27598592-methylimidazo[1,2-a]pyridine-3-carbaldehydeHCID 11396265Triphenyl{[2-(trimethylsilyl)ethoxy]methyl}phosphanium chloride

생성물 1

HCID 67159028HCID 67159028, 화합물수율 96%

실험 절차

Following procedures analogous to those described in Example 6 and use triphenyl-(2-trimethylsilanyl-ethoxymethyl)phosphonium chloride, 2-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde was converted into 2-methyl-3-[2-(2-trimethylsilanyl-ethoxy)-vinyl]-imidazo[1,2-a]pyridine (96% yield).

출처 및 근거

ORD 기록
ord-d5344747c38d4d1c8bec2d896ae763c1
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349883B2

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