Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → Quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Sodium Dithionite | HCID 24489 | — |
| 반응물 | 4-(3-Chloropropyl)morpholine | HCID 95834 | — |
| 반응물 | Gefitinib | HCID 123631 | — |
| 반응물 | 3-Hydroxy-4-methoxybenzonitrile | HCID 4912822 | — |
| 생성물 | Quinazoline | HCID 9210 | — |
반응 단계
WO 2004/024703 discloses a process for the preparation of gefitinib starting from 3-hydroxy-4-methoxy benzonitrile which involves condensation of 3-hydroxy-4-methoxy benzonitrile with morpholino propyl chloride, nitration, reduction with sodium dithionite to amino compound, hydrolysis of nitrile to amide, cyclisation in the presence of formamide to obtain quinazoline, chlorination with phosphorous oxychloride and finally condensation with chloro-fluoro aniline to obtain gefitinib. The process involves multiple steps and hence is time consuming.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08350029B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-03eb032aa21040a8a01c2c7707c6ff57 |
| 출처 메모 | uspto-grants-2013_01 |