3-Chloro-4-fluoroaniline → Gefitinib

HRID 1803015

반응식

HRID 1803015 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:22][CH3:23])=[C:9]([O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:24][C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][C:31]=1[F:32])[NH2:28]>>[CH3:23][O:22][C:8]1[CH:7]=[C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:28][C:27]3[CH:29]=[CH:30][C:31]([F:32])=[C:25]([Cl:24])[CH:26]=3)[C:11]2=[CH:10][C:9]=1[O:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

참가 물질

3

반응물 2

HCID 97083-Chloro-4-fluoroanilineHCID 226492214-Chloro-7-methoxy-6-(3-(4-morpholinyl)propoxy)quinazoline

생성물 1

HCID 123631Gefitinib

실험 절차

condensing, 4-chloro-7-methoxy-6-(3-morpholino propoxy) quinazoline of the formula VII with 3-chloro-4-fluoroaniline to obtain gefitinib of formula I.

출처 및 근거

ORD 기록
ord-e21015af40654a3b95652e7aee76f0fc
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08350029B2

연결된 노트

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