Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Xylene → Cetirizine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Xylene | HCID 7237 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(2-Chloroethoxy)acetic acid | HCID 10920584 | — |
| 반응물 | 2-(2-Chloroethoxy)acetamide | HCID 11018931 | — |
| 반응물 | 2-(2-Chloroethoxy)acetonitrile | HCID 14835913 | — |
| 반응물 | 2-Chloroethoxy acetate | HCID 18435677 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Cetirizine | HCID 2678 | — |
반응 단계
The compound (I) may be further treated with a 2-chloroethoxy acetic acid derivative such as 2-chloroethoxy acetamide or 2-chloroethoxy acetate or 2-chloroethoxy acetonitrile in the presence of a base such as sodium carbonate or potassium carbonate, and a solvent such as toluene or xylene to obtain the corresponding [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid derivative which on hydrolysis, for example, using sodium hydroxide gives levocetirizine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08350031B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-0709d4e8829142cd93bbdf1360d5fbd2 |
| 출처 메모 | uspto-grants-2013_01 |