(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine → N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

HRID 1803075

반응식

HRID 1803075 반응식
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:17]([O-])=O)[CH:13]=2)[N:8]=1>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=2)[N:8]=1

참가 물질

4

반응물 1

HCID 57647540(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine

생성물 1

HCID 43450845N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine (0.5 g, 2.0 mmol) were dissolved in ethyl acetate (25 ml). Upon addition of Pd/C (10%, 0.1 g) the reaction mixture was stirred for 45 min at ambient temperature under an atmosphere of hydrogen. Then the catalyst was filtered off, the filter washed with ethyl acetate and the filtrate evaporated. N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine was obtained as a yellow foam (0.40 g, 87%); MS: m/e=280.5 (M+H+).

후처리

  1. filtrationThen the catalyst was filtered off
  2. washthe filter washed with ethyl acetate
  3. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-2fbd740fd08441269def9e08f5e5e17a
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08350028B2

연결된 노트

불러오는 중…