Ammonium Hydroxide → 2,3-Difluoro-5-nitrophenol

HRID 1803151노트

반응식

HRID 1803151 반응식
[OH-].[NH4+].C(=O)(OCC)[O:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([F:14])[C:6]=1[F:15]>CCOC(C)=O>[F:15][C:6]1[C:7]([F:14])=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=1[OH:4]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 66859069HCID 66859069, 화합물

생성물 1

HCID 221546562,3-Difluoro-5-nitrophenol수율 85%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Step M (3): Aqueous ammonium hydroxide (5 mL) was added to a solution of 2,3-difluoro-5-nitrophenyl ethyl carbonate (250 mg, 1.0 mol) in EtOAc (4 mL). The reaction mixture was quenched with 1 N HCl. The mixture was diluted with water and extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford 2,3-difluoro-5-nitrophenol (150 mg, 85% yield).

후처리

  1. customThe reaction mixture was quenched with 1 N HCl
  2. additionThe mixture was diluted with water
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-960946d47f3c4bf8978c4a0ab66f48b5
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349880B2

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