Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phloroglucinol → 7,9-Dihydroxydibenzo[b,g][1,5]naphthyridin-6(11H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phloroglucinol | HCID 359 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Ethyl 3-aminoquinoline-2-carboxylate | HCID 12316475 | — |
| 용매 | Heptanol | HCID 8129 | — |
| 생성물 | 7,9-Dihydroxydibenzo[b,g][1,5]naphthyridin-6(11H)-one | HCID 68586139 | — |
반응 단계
3.5 g of 1,3,5-trihydroxybenzene and 62.5 mg of paratoluenesulphonic acid are added to a solution of 5 g of ethyl 3-amino-2-quinolinecarboxylate in 50 ml of heptan-1-ol. The mixture is stirred for 48 hours at reflux using a Dean Stark apparatus and then the reaction mixture is concentrated in vacuo. Chromatography on silica gel (cyclohexane/acetone 90/10) allows 5.2 g of the expected product to be isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741325B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f98ea78f58f84382a1b3d6e833a71816 |
| 출처 메모 | uspto-grants-2010_06 |