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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Methyl Ethyl Ketone → (+/-)-cis-7-Methoxy-4,4,15-trimethyl-15,15c-dihydro-4H-benzo[b][1,3]-dioxolo[4',5':3,4]chromeno[6,5-g][1,8]naphthyridin-2,8[3aH]-dione

HRID 18037
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HRID 18037 반응식
[OH:1][C@@H:2]1[C:19]2[C:18]3[N:17]([CH3:20])[C:16]4[N:15]=[C:14]5[CH:21]=[CH:22][CH:23]=[CH:24][C:13]5=[CH:12][C:11]=4[C:10](=[O:25])[C:9]=3[C:8]([O:26][CH3:27])=[CH:7][C:6]=2[O:5][C:4]([CH3:29])([CH3:28])[C@@H:3]1[OH:30].C[C:32](=[O:35])CC>C([O-])([O-])=O.[Na+].[Na+]>[CH3:27][O:26][C:8]1[C:9]2[C:10](=[O:25])[C:11]3[CH:12]=[C:13]4[CH:24]=[CH:23][CH:22]=[CH:21][C:14]4=[N:15][C:16]=3[N:17]([CH3:20])[C:18]=2[C:19]2[C@H:2]3[O:1][C:32](=[O:35])[O:30][C@H:3]3[C:4]([CH3:28])([CH3:29])[O:5][C:6]=2[CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6569Methyl Ethyl KetoneHCID 11327222(+/-)-cis-1,2-Dihydroxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7h-benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one

생성물 1

HCID 11384935(+/-)-cis-7-Methoxy-4,4,15-trimethyl-15,15c-dihydro-4H-benzo[b][1,3]-dioxolo[4',5':3,4]chromeno[6,5-g][1,8]naphthyridin-2,8[3aH]-dione

시약·촉매·용매 1

HCID 10340Sodium Carbonate용매

실험 절차

635.62 mg of N,N′-carbonyldiimidazole are added to a solution of 200 mg of the compound of Example 3 in 90 ml of 2-butanone. The reaction mixture is refluxed for 4 days under argon and then, after cooling, diluted with an aqueous 5% Na2CO3 solution (15 ml) and extracted with ethyl acetate. The organic solutions are combined, dried over anhydrous sodium sulphate, filtered and then evaporated to dryness under reduced pressure. Chromatography on silica gel (dichloromethane and then a gradient of methanol in dichloromethane of from 0.1 to 1.5%) allow 78 mg of the expected product to be isolated.

후처리

  1. temperatureThe reaction mixture is refluxed for 4 days under argon
  2. temperatureafter cooling
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous sodium sulphate
  5. filtrationfiltered
  6. customevaporated to dryness under reduced pressure
  7. customto be isolated

출처 및 근거

ORD 기록
ord-238b96d2416846d38db9e8b5e974244a
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07741325B2

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