Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| 반응물 | 4-Iodobenzoyl chloride | HCID 74373 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484733 | 101.4% |
반응 단계
To tetrahydrofuran (60 mL) were added 4-iodobenzoyl chloride (5 g), 1-(2,4-dimethylphenyl)piperazine (3.6 g) and 1N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred at room temperature overnight. Ethyl acetate was added for partitioning, the organic layer was washed with saturated brine, and the solvent was evaporated. The title compound (8 g) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08354401B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-cc3d32c8e2ab49d7b226489d80053ed9 |
| 출처 메모 | uspto-grants-2013_01 |