Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | 6-Bromonicotinic acid | HCID 238932 | — |
| 반응물 | 4-(4-Methylphenoxy)piperidine | HCID 3837497 | — |
| 반응물 | 4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate | HCID 23149411 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone | HCID 58484591 | 99.9% |
반응 단계
To a mixture of 4-(p-tolyloxy)piperidine (765 mg), 6-bromonicotinic acid (808 mg) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (1.7 g) were added chloroform (5 mL) and methanol (5 mL), and the mixture was stirred at room temperature overnight. After evaporation of the solvent, the residue was purified by column chromatography (chloroform:methanol) to give the title compound (1.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08354401B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-31d277f31d42413fbaa18166042e1a7d |
| 출처 메모 | uspto-grants-2013_01 |