(R)-4-Methyloxazolidin-2-one → (R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803979

반응식

HRID 1803979 반응식
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[CH3:14][C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1>>[CH3:13][O:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:16]1[C@H:15]([CH3:14])[CH2:19][O:18][C:17]1=[O:20])[C:6]([OH:8])=[O:7]

참가 물질

3

반응물 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 14570117Methyl 4-bromo-3-methoxybenzoate

생성물 1

HCID 58484801(R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid수율 97.5%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 45 and using methyl 4-bromo-3-methoxybenzoate (1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 45
  3. customdescribed in Preparation Example 25

출처 및 근거

ORD 기록
ord-dfc5d763c3244908b695e300cb61484a
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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