(R)-4-Methyloxazolidin-2-one → methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804028

반응식

HRID 1804028 반응식
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[F:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[F:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

참가 물질

3

반응물 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 21951878Methyl 4-bromo-3-fluorobenzoate

생성물 1

HCID 58484559methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate수율 92%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-fluorobenzoate (1.2 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

출처 및 근거

ORD 기록
ord-dcd11aec23964959813ce4c5b17fd4e6
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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