(R)-4-Methyloxazolidin-2-one → methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804029

반응식

HRID 1804029 반응식
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

참가 물질

3

반응물 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 3294148Methyl 4-bromo-3-methylbenzoate

생성물 1

HCID 58484849methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate수율 100.3%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-methylbenzoate (1.1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

출처 및 근거

ORD 기록
ord-2633152adc6e4e22b3eb0d9ed530f9c3
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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