4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804045노트

반응식

HRID 1804045 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH3:13][C:14]1[C:15]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:16][C:17]([CH3:21])=[C:18]([CH3:20])[CH:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:15]3[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[C:17]([CH3:21])[N:16]=3)[CH2:23][CH2:24]2)=[O:7])=[C:4]([F:11])[CH:3]=1

참가 물질

3

반응물 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 673810521-(3,5,6-Trimethylpyridin-2-yl)piperazine hydrochloride

생성물 1

HCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone수율 59.5%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (5 g) described in Preparation Example 52, the title compound (5 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 8
  3. customdescribed in Preparation Example 52

출처 및 근거

ORD 기록
ord-5f3c09eaaccb44269bea0e2824d76325
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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