1-(5-Bromo-3-methylpyridin-2-yl)piperazine → HCID 58484740, 화합물

반응식

[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:20][CH2:21][N:22]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:23][CH2:24]2)=[N:17][CH:18]=1

참가 물질

반응물 2

HCID 467392701-(5-Bromo-3-methylpyridin-2-yl)piperazine

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

생성물 1

HCID 58484740HCID 58484740, 화합물수율 43.4%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 69 and using 6-fluoro-4-methylnicotinic acid (931 mg) and 1-(5-bromo-3-methylpyridin-2-yl)piperazine (1.5 g), the title compound (1 g) was obtained.

후처리

customBy reaction and treatment in the same manner
customas in Preparation Example 69

출처 및 근거

ORD 기록: ord-125e8a21052c4df7ad44c96b6a00f346
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08354401B2

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