6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588, 화합물

HRID 1804091노트

반응식

HRID 1804091 반응식
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

참가 물질

3

반응물 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204, 화합물

생성물 1

HCID 58484588HCID 58484588, 화합물수율 103.8%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg), the title compound (980 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27

출처 및 근거

ORD 기록
ord-90a86ade4c79487da57f49130a31fdda
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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