6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone
반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:11]1([C:14]2[C:15]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:16][CH:17]=[C:18]([CH3:20])[CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[C:14]([CH:11]4[CH2:13][CH2:12]4)=[CH:19][C:18]([CH3:20])=[CH:17][N:16]=3)[CH2:22][CH2:23]2)=[O:8])=[CH:9][CH:10]=1참가 물질
3
실험 절차
By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (185 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine (210 mg), the title compound (170 mg) was obtained.
후처리
- customBy reaction and treatment in the same manner
- customas in Preparation Example 27