4-Iodobenzoyl chloride → [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 1804122노트

반응식

HRID 1804122 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[I:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:21]([C:20]3[CH:24]=[CH:25][C:17]([I:16])=[CH:18][CH:19]=3)=[O:22])[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 743734-Iodobenzoyl chlorideHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

생성물 1

HCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone수율 90.5%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 161 and using 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (2.46 g) described in Preparation Example 53 and 4-iodobenzoyl chloride (3.36 g), the title compound (4.72 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 161

출처 및 근거

ORD 기록
ord-3362696b3ae9429bbdabe7882674a502
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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