4-(4-Methylphenoxy)piperidine → (R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-one

HRID 1804182노트

반응식

HRID 1804182 반응식
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1>>[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:27])=[CH:24][CH:23]=1

참가 물질

3

반응물 2

HCID 38374974-(4-Methylphenoxy)piperidineHCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

생성물 1

HCID 67381285(R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-one수율 77.6%

실험 절차

By reaction and treatment in the same manner as in Example 52 and using 4-(p-tolyloxy)piperidine (1 g) and (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (1.2 g) described in Preparation Example 37, the title compound (1.6 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 52
  2. customdescribed in Preparation Example 37

출처 및 근거

ORD 기록
ord-878a4ab351534d078c1b314cc1ef2612
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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