(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804190노트

반응식

HRID 1804190 반응식
[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:3])[CH3:2].[CH3:19][C:20]1[C:21]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[N:22][CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1>>[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:33]2[CH2:34][CH2:35][N:30]([C:21]3[C:20]([CH3:19])=[CH:25][C:24]([C:26]([F:29])([F:27])[F:28])=[CH:23][N:22]=3)[CH2:31][CH2:32]2)=[O:16])=[CH:17][CH:18]=1)([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

생성물 1

HCID 67380990(R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one수율 30.7%

실험 절차

By reaction and treatment in the same manner as in Example 29 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (499 mg) described in Preparation Example 18 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (490 mg) described in Preparation Example 51, the title compound (292 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 29
  2. customdescribed in Preparation Example 51

출처 및 근거

ORD 기록
ord-777b159fbf0b40bb9066bac907350dc0
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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