(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-ethyloxazolidin-2-one

HRID 1804203노트

반응식

HRID 1804203 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[CH2:28]([C@@H:30]1[CH2:34][O:33][C:32](=[O:35])[NH:31]1)[CH3:29]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:31]4[C@H:30]([CH2:28][CH3:29])[CH2:34][O:33][C:32]4=[O:35])=[CH:3][C:4]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

참가 물질

3

반응물 2

HCID 641503(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 58484505(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

생성물 1

HCID 67380915(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-ethyloxazolidin-2-one수율 42.4%

실험 절차

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (874 mg) described in Preparation Example 61 and (R)-4-ethyloxazolidin-2-one (300 mg) described in Preparation Example 26, the title compound (399 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 1
  2. customdescribed in Preparation Example 26

출처 및 근거

ORD 기록
ord-7a3ae18a5f1541f88b97de9d62f2023c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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