(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one hydrochloride

HRID 1804226노트

반응식

HRID 1804226 반응식
[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:3])[CH3:2].[ClH:19].[CH:20]1([C:23]2[C:24]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:22][CH2:21]1>>[ClH:19].[CH:20]1([C:23]2[C:24]([N:32]3[CH2:33][CH2:34][N:35]([C:14]([C:13]4[CH:12]=[CH:11][C:10]([N:5]5[C@H:4]([CH:1]([CH3:2])[CH3:3])[CH2:8][O:7][C:6]5=[O:9])=[CH:18][CH:17]=4)=[O:16])[CH2:36][CH2:37]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:21][CH2:22]1

참가 물질

3

반응물 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 673810941-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride

생성물 1

HCID 67381205(R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one hydrochloride수율 45.9%

실험 절차

By reaction and treatment in the same manner as in Example 87 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (499 mg) described in Preparation Example 18 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (560 mg) described in Preparation Example 50, the title compound (469 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 87
  2. customdescribed in Preparation Example 50

출처 및 근거

ORD 기록
ord-ead13ed37fa14d81acd2176f154d84be
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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