5-Methyl-2-oxazolidinone → 3-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methyloxazolidin-2-one

HRID 1804285

반응식

HRID 1804285 반응식
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][CH:25]1[O:29][C:28](=[O:30])[NH:27][CH2:26]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:27]4[CH2:26][CH:25]([CH3:24])[O:29][C:28]4=[O:30])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

참가 물질

3

반응물 2

HCID 1368375-Methyl-2-oxazolidinoneHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

생성물 1

HCID 584848243-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methyloxazolidin-2-one수율 29.6%

실험 절차

By reaction and treatment in the same manner as in Example 1 and using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (93 mg) described in Preparation Example 73 and 5-methyloxazolidin-2-one (30 mg), the title compound (29 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 1

출처 및 근거

ORD 기록
ord-eba30538521a413fb8ae3a094b31646c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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