(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(5-cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-4-methyloxazolidin-2-one

HRID 1804393노트

반응식

HRID 1804393 반응식
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[CH2:25][CH2:24]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:26])[CH:3]=1.[CH3:27][C@@H:28]1[CH2:32][O:31][C:30](=[O:33])[NH:29]1>>[CH:23]1([C:20]2[CH:21]=[CH:22][C:17]([N:14]3[CH2:15][CH2:16][N:11]([C:9]([C:5]4[C:6]([F:8])=[CH:7][C:2]([N:29]5[C@H:28]([CH3:27])[CH2:32][O:31][C:30]5=[O:33])=[CH:3][C:4]=4[F:26])=[O:10])[CH2:12][CH2:13]3)=[N:18][CH:19]=2)[CH2:25][CH2:24]1

참가 물질

3

반응물 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

생성물 1

HCID 58484551(R)-3-{4-[4-(5-cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-4-methyloxazolidin-2-one수율 58.1%

실험 절차

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone (422 mg) described in Preparation Example 189 and (R)-4-methyloxazolidin-2-one (134 mg) described in Preparation Example 25, the title compound (257 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 25

출처 및 근거

ORD 기록
ord-e7875cb73b3f4390acf124101819ec23
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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