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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1804398생성일: 2026년 10월 27일

(R)-4-Methyloxazolidin-2-one → (R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one

https://huagongshe.com/reaction/1804398

반응식

참여 물질

역할이름HCID투입량
반응물(R)-4-Methyloxazolidin-2-oneHCID 2734858—
반응물5-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileHCID 58484573—
생성물(R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-oneHCID 58484637—

반응 단계

By reaction and treatment in the same manner as in Example 110 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (425 mg) described in Preparation Example 194 and (R)-4-methyloxazolidin-2-one. (121 mg) described in Preparation Example 25, the title compound (363 mg) was obtained.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08354401B2
출처 데이터셋uspto-grants-2013_01
ORD IDord-9575450010384f0ab491d5e9c6440974
출처 메모uspto-grants-2013_01