Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoate → 3-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804407

반응식

HRID 1804407 반응식
[O:1]=[C:2]1[N:6]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1>>[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:6]4[CH2:5][CH2:4][O:3][C:2]4=[O:1])=[CH:17][CH:16]=3)=[O:13])[CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1

참가 물질

3

반응물 2

HCID 616604Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoateHCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazine

생성물 1

HCID 584848113-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one수율 15.8%

실험 절차

By reaction and treatment in the same manner as in Example 34 and using ethyl 4-(2-oxooxazolidin-3-yl)benzoate (353 mg) described in Preparation Example 12 and 1-(2,6-dimethylpyridin-3-yl)piperazine (287 mg) described in Preparation Example 153, the title compound (90.2 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 34
  2. customdescribed in Preparation Example 153

출처 및 근거

ORD 기록
ord-2f016fdd0c174f72b85a00e4faed29d4
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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