Potassium Hydroxide → 3-(2-Oxoimidazolidin-1-yl)benzonitrile
반응식
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=1)=[O:6].[OH-].[K+]>C(O)C>[O:6]=[C:5]1[NH:4][CH2:3][CH2:2][N:7]1[C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[C:14]#[N:15]참가 물질
4
실험 절차
110.00 g (490 mmol) 1-(2-chloro-ethyl)-3-(3-cyano-phenyl)-urea are dissolved in 2000 ml of ethanol at 50° C. and a solution of 42.00 g (640 mmol) potassium hydroxide in 390 ml of ethanol is added within 1.5 hours. The reaction mixture is stirred for 16 hours at ambient temperature, then the precipitate formed is suction filtered, washed with water and dried.
후처리
- customthe precipitate formed
- filtrationfiltered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-11c7c62c2f054b609d970bfa20080a3c
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08354418B2
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