Water → HCID 57698624, 화합물

HRID 1804546노트

반응식

HRID 1804546 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:22])[O:18][CH2:19][CH2:20]Cl)[CH:13]=[CH:14][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+].O>O1CCCC1>[O:22]=[C:17]1[N:16]([C:12]2[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=2)[CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:20][CH2:19][O:18]1

참가 물질

5

반응물 3

HCID 962WaterHCID 23665647Potassium tert-butoxideHCID 57698618HCID 57698618, 화합물

생성물 1

HCID 57698624HCID 57698624, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.20 g (3.65 mmol) 2-chloro-ethyl [3-(tert-butoxycarbonylamino-methyl)-phenyl]-carbamate and 0.850 g (7.58 mmol) potassium tert.butoxide are placed at 0° C. in 30 ml of tetrahydrofuran and the mixture is stirred for 3 hours at ambient temperature. Then the reaction mixture is added to water and extracted with dichloromethane. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography.

후처리

  1. extractionextracted with dichloromethane
  2. customThe organic phase is dried
  3. customevaporated to dryness
  4. customThe residue is purified by chromatography

출처 및 근거

ORD 기록
ord-20eaf5ef5883475ca85bc90d7be04b12
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354418B2

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