Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

HRID 1804565노트

반응식

HRID 1804565 반응식
[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:6][N:5]=1)([CH3:3])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH2:11])=[N:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57637115Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate

생성물 1

HCID 242544832-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4.00 g (15.67 mmol) tert-butyl [2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

후처리

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-e0ab4ef7536c4e8c862400cbe78f2ecb
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354418B2

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