(2-Fluoro-3-methoxy-4-nitrophenyl)(morpholino)methanone → (4-Amino-2-fluoro-3-methoxyphenyl)(morpholino)methanone

HRID 1804683노트

반응식

HRID 1804683 반응식
[F:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([N+:10]([O-])=O)[CH:5]=[CH:4][C:3]=1[C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14]>[Pd].C(O)C>[NH2:10][C:6]1[CH:5]=[CH:4][C:3]([C:13]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[O:14])=[C:2]([F:1])[C:7]=1[O:8][CH3:9]

참가 물질

4

반응물 1

HCID 70099135(2-Fluoro-3-methoxy-4-nitrophenyl)(morpholino)methanone

생성물 1

HCID 58539264(4-Amino-2-fluoro-3-methoxyphenyl)(morpholino)methanone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspenion of (2-fluoro-3-methoxy-4-nitrophenyl)(morpholino)methanone (0.20 g) and palladium on carbon (0.1 g, 10 wt %) in ethanol was stirred under hydrogen for 18 hours. The reaction then filtered through celite and concentrated to give (4-amino-2-fluoro-3-methoxyphenyl)(morpholino)methanone.

후처리

  1. customThe reaction
  2. filtrationthen filtered through celite and
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ebc0b67471c84d5ba33200a119ebf431
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354420B2

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