(-)-Dibenzoyltartrate → 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

HRID 1804761노트

반응식

HRID 1804761 반응식
[CH3:1][CH:2]1[CH:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[C:15]([C:23]([C:38]([O-:40])=[O:39])([OH:37])[C:24]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:28])[C:25]([O-:27])=[O:26])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(OCC)(=O)C>[C:29]([C:24]([C:25]([OH:27])=[O:26])([OH:28])[C:23]([C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([OH:37])[C:38]([OH:40])=[O:39])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1

참가 물질

4

반응물 2

HCID 21978704(-)-DibenzoyltartrateHCID 668421342,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester

생성물 1

HCID 1317301552,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester (5) (9.6 g, 48 mmol) is dissolved in 50 ml of ethyl acetate. A solution of (−)-dibenzoyltartrate (8.6 g, 24 mmol) in ethyl acetate is added drop wise. The precipitate is filtrated off and washed with cold ethyl acetate to yield colourless crystals.

후처리

  1. filtrationThe precipitate is filtrated off
  2. washwashed with cold ethyl acetate
  3. customto yield colourless crystals

출처 및 근거

ORD 기록
ord-5dd345f6fc7e4ea281f841b92d6979a7
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354431B2

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